Whole Network Challenges Education Information Notable Research Resources Views

 

Why Some Diabetes Drugs Increase Risk of Heart Failure

Filed in archive Developments , Research by Gloria Gamat on September 17, 2007

Diabetes drugs that are agonists of the peroxisome proliferator activated receptorlinks (PPAR) gamma such as pioglitazone and rosiglitazone are associated with increased risk of heart failure.

Why Some Diabetes Drugs Increase Risk of Heart Failure



Remember the case of the controversial diabetes drug Avandia®? Exactly the case!

But why agonists of PPAR gamma can increase risk of heart failure in some patients being treated with it is potentially explained by a new mice study by a team from Columbia University in New York:
Fat and carbohydrates accumulated in the heart muscle cells of these mice causing a deterioration in heart function (a process known as glucolipotoxicity).

Administration of a PPAR-gamma agonist to these mice exacerbated their heart dysfunction.

The authors therefore conclude that the adverse effect of PPAR-gamma agonists on heart function in humans might be due to glucolipotoxocity.


Example of pioglitazone is Takeda Pharma's Actos® while rosiglitazone is the controversial Avandia® by GlaxoSmithKline.

Remember that both drugs is not for all type 2 diabetics.

Findings appear in the Journal of Clinical Investigation.

Source: Science Daily






Permalink: Why Some Diabetes Drugs Increase Risk of Heart Failure
Tags: pioglitazone  rosiglitazone  diabetes  heart  failure  2007  heart+failure  diabetes+drugs 

Trackback: http://www.creative-weblogging.com/cgi-bin/mt-tb.pl/92011





RSSrss   | See all blog subscribe options
Google google   |   What is RSS?
Yahoo! yahoo
Addthis Subscribe using any feed reader!
Bloglines Bloglines
Newsletter
Grouptivity

Use the search to look for other interesting posts

HealthCentral Top Site Award


 
  • Advertise with us

  • Learn more about our advertising options or email advertising - at - creative-weblogging.com or give us a call at +1 (650) 331 4900.


  • Testimonials

  • 'Daily Diabetic is already one of my favorite resources for diabetes news. I enjoy the positive approach it takes, and recommend it to anyone with diabetes, or to anyone who wants to help people with diabetes.' -Jessica Thomas, Type 1 Diabetic

    'Thank you for helping me stay in touch with the latest research.'-Scott Phillips

    'This is just the worst for children. I dear friend of mine has a grand daughter who was recently diagnosed with Type I diabetes so we're reading up and gathering information and help and prefer it from REAL people. I thank you for sharing all the great information here as it's been a great help.' -JR

Health & Medicine - Top Blogs Philippines

  • Other blogs in the same channel in the Creative Weblogging Network







 

Tagcloud: Blogs, Blogging & Blogosphere Challenges Developments Diabetics' Device Diet Education Exercise Family Matters Friends Fun Information Inspiration Interviews Lifestyle News Notable Research Resources Sponsored Post Treatment Views