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Osteopontin is Why Obesity Lead to Diabetes

Filed in archive Developments , Research by Gloria Gamat on September 12, 2007

At least according to the new data generated in mice by a team from University of Kentucky College of Medicine, Lexington.

Obesity has always been linked to insulin resistance, which most often lead to type 2 diabetes.

Osteopontin is Why Obesity Lead to Diabetes


According to this mice study, although mice lacking osteopontin became obese when fed a high-fat diet, they did not become as insulin resistantlinks as normal mice fed the same diet.

[Osteopontin is an extracellular matrix protein and proinflammatory cytokine that is required for macrophage infiltration of a tissue during an immune response.]

This decrease in insulin resistance was associated with decreased accumulation of macrophages in the adipose tissue leading the authors to conclude that osteopontin has a key role in linking obesity to the development of insulin resistance in mice.


I wonder when all these will be translated into humans? Let's wait and see...

Findings have been reported (a pdf file) in the Journal of Clinical Investigation.

Source: University of Kentucky






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Tags: osteopontin  obesity  insulin  resistance  type  2  diabetes  2007  osteopontin+obesity 

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