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Control Beta-cells Proliferation, Control Diabetes

Filed in archive Research by Gloria Gamat on September 18, 2007

In both type 1 and type 2 diabetes, the root cause is the insufficiency of pancreatic beta cells (the ones that produce insulin) to control blood sugar levels.

Control Beta-cells Proliferation, Control Diabetes



What if scientists found out how to control the proliferation of beta-cells? Then that will a great target for the treatment of this epidemic condition.

Such exactly is what a team from the David Geffen School of Medicine in Los Angeles is doing and have in fact identified that the protein Skp2 has a critical role in regulating beta-cell proliferation in mice.

The authors observed that mice lacking Skp2 developed more severe insulin resistance and more overt diabetes after being fed a high-fat diet than normal mice.

This was associated with decreased degradation of p27 in beta-cells, which prevented the cells from proliferating.

The authors therefore suggest that Skp2-mediated p27 degradation in beta-cells might have a role in regulating beta-cell proliferation in response to metabolic needs.


Let's wait and see if the same will be true in humans.

Find more details from the Journal of Clinical Investigation.

Source: Science Daily


Photo Credit: Medline Plus


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Tags: type  1  diabetes  type  2  diabetes  pancreatic  beta  cells  control  beta+cells 

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