Cancer Drug Gleevec May Treat Type 1 Diabetes
Filed in archive Research , Treatment on November 18, 2008
Experiments with mice by researchers at the University of California San Francisco (UCSF) found that the popular cancer drug Gleevec (and a similar drug called Sutent) may prevent the onset of type 1 diabetes.
According to lead researcher Jeffrey Bluestone, director of the Diabetes Center at the University of California, San Francisco:
"Although targeted to the Bcr-Abl kinase, Gleevec has been shown to affect related kinases including platelet-derived growth factor potentially involved in various cell types critical to the development and progression of autoimmune diseases such as type 1 diabetes.
The study shows that this class of drugs could prevent and reverse diabetes in a mouse model of type 1 diabetes. Moreover, a significant percentage of the animals remain in long-term remission even after discontinuation of the therapy."
Findings were published in this week's online issue of the Proceedings of the National Academy of Sciences (PNAS).
Gleevec is known for use in the treatment of leukemia and other cancer types.
The study shows that this class of drugs could prevent and reverse diabetes in a mouse model of type 1 diabetes. Moreover, a significant percentage of the animals remain in long-term remission even after discontinuation of the therapy."
Tags: type 1 diabetes Gleevec 2008 type+diabetes cancer+drug drug+gleevec
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Response from:
Josee Robillard
(11/21/08 4:23am)
Response from:
Satria
(11/22/08 5:22am)
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Response from:
Ajlouny
(12/04/08 1:52pm)
It's so great to see advancement in the fight on diabetes. I feel like were getting closer and closer to a cure on a disease that is effecting so many people.
Response from:
L
(05/03/10 1:02am)
I am a type 2 diabetic, and was recently diagnosed with Hypereosinophilic Syndrome (an ultra rare form of Bone Marrow cancer), for which Gleevec is the preferred treatment.
Taking 2000mg Metformin (1000mg twice daily) and Januvia 300mg once a day, my A1C was between 9 and 11.
Post diagnosis and starting Gleevec, my A1C for the past 6 months has been below 7.
In my case, eosinophils (a type of white blood cell) bind to the protein receptors that insulin normally binds to, so it was making my type 2 much worse.
Taking 2000mg Metformin (1000mg twice daily) and Januvia 300mg once a day, my A1C was between 9 and 11.
Post diagnosis and starting Gleevec, my A1C for the past 6 months has been below 7.
In my case, eosinophils (a type of white blood cell) bind to the protein receptors that insulin normally binds to, so it was making my type 2 much worse.
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So,you can send me every details or others research about that subject.
If Gleevec is efficiency. How they work. He need to take a pills every day ?