Cancer Drug Gleevec May Treat Type 1 Diabetes
Filed in archive Research , Treatment by Gloria Gamat on November 19, 2008
According to lead researcher Jeffrey Bluestone, director of the Diabetes Center at the University of California, San Francisco:
"Although targeted to the Bcr-Abl kinase, Gleevec has been shown to affect related kinases including platelet-derived growth factor potentially involved in various cell types critical to the development and progression of autoimmune diseases such as type 1 diabetes.
The study shows that this class of drugs could prevent and reverse diabetes in a mouse model of type 1 diabetes. Moreover, a significant percentage of the animals remain in long-term remission even after discontinuation of the therapy."
Findings were published in this week's online issue of the Proceedings of the National Academy of Sciences (PNAS).
Gleevec is known for use in the treatment of leukemia and other cancer types.
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